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Biotechnology and Applied Biochemistry (2003) 37, (45–50) (Printed in Great Britain)

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Measurement of NADH concentration in normal and malignant human tissues from breast and oral cavity

Abha Uppal and Pradeep Kumar Gupta¹

Biomedical Applications Section, Centre For Advanced Technology, Indore, India 452013

Key words: autofluorescence, diagnosis of cancer.

¹To whom correspondence should be addressed (e-mail pkgupta@cat.ernet.in).

We report measurements of the concentration of NADH from malignant and non-malignant sites of tissues resected from patients suffering from cancer of the breast or oral cavity. The concentration of NADH was found to be significantly higher in malignant breast-tissue sites as compared with normal breast tissue, whereas the opposite result was obtained with malignant and normal tissues from the oral cavity. These results confirm the inferences made previously, from spectroscopic studies, and are consistent with other biochemical measurements reported in breast and oral cavity tissues.

Received 7 June 2002/18 September 2002; accepted 23 September 2002

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